Perspectives on recent advances in the understanding and treatment of Parkinson’s disease
Identifieur interne : 000075 ( France/Analysis ); précédent : 000074; suivant : 000076Perspectives on recent advances in the understanding and treatment of Parkinson’s disease
Auteurs : A. H. Schapira [Royaume-Uni] ; Yves Agid [France] ; P. Barone [Italie] ; P. Jenner [Royaume-Uni] ; M. R. Lemke [Allemagne] ; Werner Poewe [Autriche] ; Olivier Rascol [France] ; H. Reichmann [Allemagne] ; E. Tolosa [Espagne]Source :
- European Journal of Neurology [ 1351-5101 ] ; 2009-10.
English descriptors
- KwdEn :
Abstract
There have been numerous important recent advances in our understanding of the causes of Parkinson’s disease (PD), the treatments available and how these are best applied for the long‐term management of patients. Novel genes causing familial PD have been discovered and mechanisms leading to cell dysfunction and death identified. The PD prodrome is now a subject of great interest and clinical markers are being defined that may in future, together with biochemical markers, support an early, pre‐motor diagnosis of PD. This will become important as new therapies are developed to modify disease progression. In the interim, the optimization of existing therapies remains an important priority. The value of existing and novel continuous drug delivery systems in PD is seen as providing simplified regimens, maintenance of motor control, reduction in motor complications and improved patient adherence to drug use.
Url:
DOI: 10.1111/j.1468-1331.2009.02793.x
Affiliations:
- Allemagne, Autriche, Espagne, France, Italie, Royaume-Uni
- Angleterre, District de Dresde, Grand Londres, Hambourg, Midi-Pyrénées, Saxe (Land), Tyrol (Land), Île-de-France
- Dresde, Hambourg, Innsbruck, Londres, Paris, Toulouse
- Hôpital de la Salpêtrière, Université Toulouse III - Paul Sabatier, Université de Toulouse, Université de médecine d'Innsbruck
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- to stream France, to step Extraction: 000075
Links to Exploration step
ISTEX:D88BCA9904F670DD3121DAAB11B4163D17FFBE3ELe document en format XML
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Barone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Naples, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Jenner, P" sort="Jenner, P" uniqKey="Jenner P" first="P." last="Jenner">P. Jenner</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Diseases Research Group, School of Biomedical and Health Sciences, King’s College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lemke, M R" sort="Lemke, M R" uniqKey="Lemke M" first="M. R." last="Lemke">M. R. Lemke</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Kiel, Kliniken Alsterdorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Poewe, W" sort="Poewe, W" uniqKey="Poewe W" first="W." last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">Olivier Rascol</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Departments of Clinical Pharmacology and Neurosciences, INSERM CIC‐9302 and UMR‐825, Toulouse University Hospital, Toulouse</wicri:regionArea><placeName><settlement type="city">Toulouse</settlement></placeName><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Midi-Pyrénées</region></placeName><orgName type="university" n="3">Université Toulouse III - Paul Sabatier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Toulouse</orgName></affiliation></author><author><name sortKey="Reichmann, H" sort="Reichmann, H" uniqKey="Reichmann H" first="H." last="Reichmann">H. Reichmann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinikum Carl Gustav Carus, an der Technischen Universität Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Tolosa, E" sort="Tolosa, E" uniqKey="Tolosa E" first="E." last="Tolosa">E. 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Novel genes causing familial PD have been discovered and mechanisms leading to cell dysfunction and death identified. The PD prodrome is now a subject of great interest and clinical markers are being defined that may in future, together with biochemical markers, support an early, pre‐motor diagnosis of PD. This will become important as new therapies are developed to modify disease progression. In the interim, the optimization of existing therapies remains an important priority. The value of existing and novel continuous drug delivery systems in PD is seen as providing simplified regimens, maintenance of motor control, reduction in motor complications and improved patient adherence to drug use.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Dresde</li><li>Grand Londres</li><li>Hambourg</li><li>Midi-Pyrénées</li><li>Saxe (Land)</li><li>Tyrol (Land)</li><li>Île-de-France</li></region><settlement><li>Dresde</li><li>Hambourg</li><li>Innsbruck</li><li>Londres</li><li>Paris</li><li>Toulouse</li></settlement><orgName><li>Hôpital de la Salpêtrière</li><li>Université Toulouse III - Paul Sabatier</li><li>Université de Toulouse</li><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Schapira, A H" sort="Schapira, A H" uniqKey="Schapira A" first="A. 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